Semax

Semax is a synthetic peptide analogue based on a short fragment of adrenocorticotropic hormone (the ACTH 4-7 region), extended with a proline-glycine-proline sequence that increases its stability as a defined molecule. It is registered under CAS 80714-61-0 with the molecular formula C₃₇H₅₁N₉O₁₀S and a reported mass of approximately 813.9 Da. As a fully synthetic sequence it is reproducible from lot to lot, and it is offered solely as a research-grade peptide for qualified laboratory use within the Cognitive Research category.

Manufactured by solid-phase peptide synthesis, Semax is supplied as a white lyophilized powder in 5mg and 10mg presentations. The freeze-dried format is selected because it produces a dry, stable solid that ships and stores reliably under cold conditions, and the peptide readily dissolves in water-based research preparations when a working solution is prepared for an in-vitro protocol. The two presentation sizes let researchers match quantity to the scale of an experiment. Semax contains a single sulfur-bearing methionine residue, which is worth noting during handling because methionine can be susceptible to oxidation; minimizing exposure to air and keeping solutions cold are common precautions. Working solutions are often prepared immediately before use rather than stored for extended periods, which limits oxidation of the methionine residue.

Analytical characterization is performed on each lot using two orthogonal techniques. Reverse-phase HPLC resolves the target from synthesis-related impurities using a solvent gradient, presenting it as a single dominant peak under UV detection so that chromatographic purity can be evaluated. LC-MS then confirms molecular identity by comparing the measured mass to the expected mass of the sequence. Because the sequence carries an oxidation-prone methionine residue, the LC-MS profile is also a useful check that the measured mass corresponds to the intact, unoxidized peptide for that lot.

Recommended research handling follows standard peptide practice: store the lyophilized powder at -20 °C, protected from light, and keep any reconstituted material cold while minimizing freeze–thaw cycles. Dividing a reconstituted stock into single-use aliquots is a common way to maintain a stable analytical reference across repeated experiments and to avoid repeatedly warming and refreezing the bulk solution. Buffer, working concentration, and handling parameters are set by the researcher.

Each order ships with lot-traceable documentation — Certificate of Analysis, RP-HPLC purity report, and independent third-party report — keyed to a verifiable lot identifier that links the records to the physical material. Semax is supplied for laboratory research use only; it is not intended for human or veterinary consumption and carries no therapeutic or diagnostic representation of any kind.