This profile is a documentation-focused reference for Semax as a research material. It sets out the molecule's identity, how each lot is characterized analytically, the documentation supplied, and the storage and handling considerations a laboratory typically records. It is written for evaluating a material on paper — not as a description of any use, effect, or application, and it makes no such claims.
For current presentations and lot-specific values, see the Semax product page. This article provides the analytical and documentation context behind those figures.
Molecular Identity and Structure
Semax is a synthetic peptide analogue based on a short fragment of adrenocorticotropic hormone (the ACTH 4-7 region), extended with a proline-glycine-proline sequence that increases its stability as a defined molecule. As a fully synthetic sequence it is reproducible from lot to lot.
It is catalogued under CAS registry number 80714-61-0, with the molecular formula C37H51N9O10S and a reported mass of approximately 813.9 Da. The sulfur in the formula reflects a methionine residue, a detail that informs how the material is handled.
Specifications at a Glance
The following reference values describe the material as characterized. Lot-specific figures are always those printed on the accompanying Certificate of Analysis, which takes precedence over any general reference.
| Attribute | Reference value |
|---|---|
| CAS number | 80714-61-0 |
| Molecular formula | C37H51N9O10S |
| Reported mass | ~813.9 Da |
| Basis | ACTH(4-7) analogue + Pro-Gly-Pro |
| Physical form | White lyophilized powder |
| Identity method | LC-MS |
| Purity method | RP-HPLC (area %) |
| Storage | -20 °C, protected from light |
| Classification | Research use only |
Analytical Characterization
Two complementary, orthogonal methods characterize each lot.
Purity — reverse-phase HPLC
Reverse-phase HPLC resolves the target peptide from synthesis-related impurities and reports purity as an area-percent value for the tested sample under the stated method.
Identity — LC-MS
LC-MS confirms the material by measuring its molecular mass and comparing it to the theoretical value for the sequence. The distinction between purity and identity is explained in how identity and purity are verified.
Documentation and Lot Traceability
Each lot is supplied with a Certificate of Analysis recording purity, mass confirmation, and release date (see the guide to Certificates of Analysis), the supporting RP-HPLC purity report, and an independent third-party analytical report. A unique lot identifier ties these records to the physical material.
Storage and Handling Considerations
Semax is stored as a lyophilized powder at -20 °C, protected from light. Because it contains a methionine residue that can be susceptible to oxidation, minimizing exposure to air and keeping reconstituted material cold are common precautions, and working solutions are often prepared shortly before use rather than stored for extended periods. Reconstituted stock is typically aliquoted to limit freeze–thaw cycling. General principles are covered in research material storage practices.
Research Context
Semax appears in the laboratory research literature as a synthetic peptide of interest. This profile intentionally does not describe, summarize, or imply any biological activity, effect, outcome, or application. Any research use is defined and bounded by the investigating laboratory's protocols, institutional SOPs, and applicable safety and regulatory requirements.
What This Profile Does and Does Not Establish
This is a documentation reference. It does not, on its own, establish any of the following:
- That the material is appropriate for a specific research workflow — suitability is a laboratory determination made against institutional SOPs.
- That every unit in a shipment is identical to a tested sample; analysis is performed on a sample, not on each container.
- Any biological effect, activity, or outcome — none is claimed or implied.
- Fitness for human or veterinary use, diagnosis, treatment, or consumption. Semax is supplied for laboratory research use only.
Key Takeaways
- Semax is a synthetic ACTH(4-7) analogue (CAS 80714-61-0; ~813.9 Da), supplied as a lyophilized powder for research use only.
- Identity is confirmed by LC-MS; purity is reported by RP-HPLC — two distinct, complementary methods.
- Its methionine residue makes air exposure and warm storage worth minimizing during handling.
- Each lot carries a COA, an RP-HPLC purity report, and an independent third-party report tied by a lot identifier.
