MOTs-c

MOTS-C is a mitochondrial-derived peptide — a sixteen-residue sequence encoded within the 12S ribosomal RNA region of the mitochondrial genome rather than the nuclear genome. It is catalogued under CAS 1627580-64-6 with the molecular formula C₁₀₁H₁₉₆N₃₄O₃₂S and a reported mass of approximately 2174.9 Da. The supplied material is a defined synthetic version of this sequence, reproducible from lot to lot, and it is offered exclusively as a research material for in-vitro laboratory investigation within the Metabolic Research category.

Produced by solid-phase peptide synthesis, MOTS-C is presented as a white lyophilized powder and offered in 10mg and 20mg presentations to accommodate different research scales. The freeze-dried format yields a dry, stable solid that supports cold-chain shipping and storage, and it reconstitutes reliably into water-based research preparations for bench work. The two size options let researchers select the quantity appropriate to a given analytical or in-vitro study. At sixteen residues and roughly 2175 Da, MOTS-C is a mid-sized peptide; researchers often allow the solvent a short equilibration period and swirl gently rather than vortexing vigorously to bring the full quantity into solution. Recording the reconstitution date against the lot identifier helps track the age of a working solution.

Each lot undergoes analytical characterization with two complementary methods. RP-HPLC separates the sixteen-residue peptide from synthesis-related impurities using a solvent gradient and resolves it as a dominant chromatographic peak under UV detection, allowing chromatographic purity to be assessed. LC-MS confirms molecular identity by matching the measured mass to the theoretical value for the sequence. For a peptide of this length, assembled over many synthesis cycles, the chromatographic profile is a valuable check that the full-length sequence predominates over shorter truncated by-products.

For research storage and handling, the lyophilized powder is held at -20 °C and protected from light. Once reconstituted with a solvent appropriate to the protocol, solutions are typically aliquoted into single-use volumes and kept cold to limit freeze–thaw cycling, which helps preserve a consistent reference across measurements. The reconstitution solvent, working concentration, and handling regime are determined by the researcher according to the requirements of the specific experiment.

Lot-traceable documentation ships with every order: the Certificate of Analysis, the RP-HPLC purity report, and the independent third-party report, each linked to a verifiable lot identifier that ties the records to the supplied material. MOTS-C is provided for laboratory research use only. It is not a drug, food, or supplement and is not intended for human consumption, therapeutic use, diagnostic use, or veterinary use.