This profile is a documentation-focused reference for MOTS-C as a research material. It sets out the molecule's identity, how each lot is characterized analytically, the documentation supplied, and the storage and handling considerations a laboratory typically records. It is written for evaluating a material on paper — not as a description of any use, effect, or application, and it makes no such claims.
For current presentations and lot-specific values, see the MOTS-C product page. This article provides the analytical and documentation context behind those figures.
Molecular Identity and Structure
MOTS-C is a mitochondrial-derived peptide — a sixteen-residue sequence encoded within the 12S ribosomal RNA region of the mitochondrial genome rather than the nuclear genome. The supplied material is a defined synthetic version of this sequence, which is what allows consistent reproduction and lot-to-lot comparison.
It is catalogued under CAS registry number 1627580-64-6, with the molecular formula C101H196N34O32S and a reported mass of approximately 2174.9 Da. The sulfur in the formula reflects a methionine residue.
Specifications at a Glance
The following reference values describe the material as characterized. Lot-specific figures are always those printed on the accompanying Certificate of Analysis, which takes precedence over any general reference.
| Attribute | Reference value |
|---|---|
| CAS number | 1627580-64-6 |
| Molecular formula | C101H196N34O32S |
| Reported mass | ~2174.9 Da |
| Sequence length | 16 residues |
| Physical form | White lyophilized powder |
| Identity method | LC-MS |
| Purity method | RP-HPLC (area %) |
| Storage | -20 °C, protected from light |
| Classification | Research use only |
Analytical Characterization
Two complementary, orthogonal methods characterize each lot.
Purity — reverse-phase HPLC
Reverse-phase HPLC separates the sixteen-residue peptide from synthesis-related impurities and reports purity as an area-percent value for the tested sample under the stated method.
Identity — LC-MS
LC-MS confirms identity by matching the measured mass to the theoretical value for the sequence. The distinction between purity and identity is explained in how identity and purity are verified, and the role of a separate laboratory in independent third-party verification.
Documentation and Lot Traceability
Each lot is supplied with a Certificate of Analysis recording purity, mass confirmation, and release date, the supporting RP-HPLC purity report, and an independent third-party analytical report. A unique lot identifier ties these records to the physical material — the principle covered in batch traceability and lot documentation.
Storage and Handling Considerations
MOTS-C is stored as a lyophilized powder at -20 °C, protected from light. At sixteen residues and roughly 2175 Da it is a mid-sized peptide; allowing the solvent a short equilibration period and swirling gently rather than vortexing vigorously helps bring the full quantity into solution. Reconstituted material is typically aliquoted into single-use volumes and kept cold to limit freeze–thaw cycling. Solvent, concentration, and handling are determined by the researcher against the protocol.
Research Context
MOTS-C appears in the laboratory research literature as a mitochondrial-derived peptide of interest. This profile intentionally does not describe, summarize, or imply any biological activity, effect, outcome, or application. Any research use is defined and bounded by the investigating laboratory's protocols, institutional SOPs, and applicable safety and regulatory requirements.
What This Profile Does and Does Not Establish
This is a documentation reference. It does not, on its own, establish any of the following:
- That the material is appropriate for a specific research workflow — suitability is a laboratory determination made against institutional SOPs.
- That every unit in a shipment is identical to a tested sample; analysis is performed on a sample, not on each container.
- Any biological effect, activity, or outcome — none is claimed or implied.
- Fitness for human or veterinary use, diagnosis, treatment, or consumption. MOTS-C is supplied for laboratory research use only.
Key Takeaways
- MOTS-C is a synthetic 16-residue mitochondrial-derived peptide (CAS 1627580-64-6; ~2174.9 Da), supplied as a lyophilized powder for research use only.
- Identity is confirmed by LC-MS; purity is reported by RP-HPLC — two distinct, complementary methods.
- Each lot carries a COA, an RP-HPLC purity report, and an independent third-party report tied by a lot identifier.
- Reported values describe a tested sample under stated methods — not suitability, uniformity, or any use.
