Tesamorelin

Tesamorelin is a synthetic forty-four-amino-acid peptide described in the scientific literature as a stabilized analog of growth-hormone-releasing factor (GRF, also written GHRH), in which the GRF(1-44) sequence carries a trans-3-hexenoyl group at its N-terminus. It holds the CAS registry number 218949-48-5 and the molecular formula C₂₂₁H₃₆₂N₆₄O₆₈S, with a reported mass of approximately 5135.8 Da. As a fully defined synthetic sequence rather than an extract, it is reproducible from lot to lot, and it is supplied strictly as a research material for in-vitro laboratory work by qualified professionals within the Growth Factors research category.

Each batch is manufactured by solid-phase peptide synthesis (SPPS), in which the chain is assembled one residue at a time on a solid support before cleavage and purification, and it is presented as a white lyophilized (freeze-dried) powder. At forty-four residues it is one of the longer chains in the catalog, so the finished material is built over many synthesis cycles, and its formula includes a single sulfur atom reflecting a sulfur-containing residue in the sequence. Dissolution into a water-based research preparation can take slightly longer than for shorter peptides; letting the solvent stand briefly and swirling gently rather than shaking helps bring the full quantity into solution while limiting foaming. Lyophilization removes water from the purified material, which improves shelf stability, simplifies cold-chain shipping, and supports consistent handling at the bench. The material in this listing is offered in a 10mg presentation intended for analytical and in-vitro research applications, and researchers frequently record the reconstitution date alongside the lot identifier so that the age of a working solution can be tracked against the analytical reference on its Certificate of Analysis.

Identity and purity are characterized for every lot using two complementary analytical methods. Purity is assessed by reverse-phase high-performance liquid chromatography (RP-HPLC), which uses a solvent gradient to separate the target peptide from synthesis-related impurities and resolves it as a single dominant chromatographic peak detected by UV absorbance. Identity is confirmed by liquid chromatography–mass spectrometry (LC-MS), which measures the molecular mass and compares it against the theoretical mass calculated from the sequence. Because a forty-four-residue chain is assembled over many coupling steps, the chromatographic profile is a particularly useful check that the full-length sequence dominates the finished material rather than truncated by-products, while the mass measurement independently confirms the intended molecule. The two techniques probe different properties — chromatographic behavior and molecular mass — so they provide orthogonal confirmation that the material matches its specification.

For research handling, the lyophilized powder should be stored at -20 °C and protected from light. Once a stock is reconstituted with an aqueous solvent appropriate to the protocol, peptide solutions are generally divided into single-use aliquots to limit repeated freeze–thaw cycles, which helps preserve a stable analytical reference between measurements. Reconstitution solvent, working concentration, and storage of the prepared solution are determined by the researcher according to the requirements of the specific experiment.

Every order ships with lot-traceable documentation: a Certificate of Analysis recording the lot-specific purity, mass confirmation, and release date, together with the RP-HPLC purity report and the independent third-party report. The unique lot identifier ties all of these records to the physical material, so researchers can verify the lot against its documentation before use. Tesamorelin is supplied for laboratory research use only — it is not a drug, food, cosmetic, or dietary supplement, and it is not intended for human consumption, therapeutic use, diagnostic use, or veterinary use.