This profile is a documentation-focused reference for Epithalon as a research material. It sets out the molecule's identity, how each lot is characterized analytically, the documentation supplied, and the storage and handling considerations a laboratory typically records. It is written for evaluating a material on paper — not as a description of any use, effect, or application, and it makes no such claims.
For current presentations and lot-specific values, see the Epithalon product page. This article provides the analytical and documentation context behind those figures.
Molecular Identity and Structure
Epithalon (also written epitalon) is a synthetic tetrapeptide with the sequence alanine-glutamate-aspartate-glycine (Ala-Glu-Asp-Gly) — the synthetic counterpart of a peptide originally described in studies of pineal extracts. With only four residues it is one of the smaller peptides in the catalog, and as a fully defined synthetic sequence it is reproducible from lot to lot.
It is catalogued under CAS registry number 307297-39-8, with the molecular formula C14H22N4O10 and a reported mass of approximately 390.3 Da.
Specifications at a Glance
The following reference values describe the material as characterized. Lot-specific figures are always those printed on the accompanying Certificate of Analysis, which takes precedence over any general reference.
| Attribute | Reference value |
|---|---|
| CAS number | 307297-39-8 |
| Molecular formula | C14H22N4O10 |
| Reported mass | ~390.3 Da |
| Sequence | Ala-Glu-Asp-Gly (4 residues) |
| Physical form | White lyophilized powder |
| Identity method | LC-MS |
| Purity method | RP-HPLC (area %) |
| Storage | -20 °C, protected from light |
| Classification | Research use only |
Analytical Characterization
Two complementary, orthogonal methods characterize each lot.
Purity — reverse-phase HPLC
Reverse-phase HPLC resolves the tetrapeptide from synthesis-related impurities and reports purity as an area-percent value for the tested sample under the stated method.
Identity — LC-MS
LC-MS confirms the material by measuring its molecular mass and comparing it to the theoretical value for the four-residue sequence. The distinction between purity and identity is explained in how identity and purity are verified.
Documentation and Lot Traceability
Each lot is supplied with a Certificate of Analysis recording purity, mass confirmation, and release date (see the guide to Certificates of Analysis), the supporting RP-HPLC purity report, and an independent third-party analytical report. A unique lot identifier ties these records to the physical material — the principle covered in batch traceability and lot documentation.
Storage and Handling Considerations
Epithalon is stored as a lyophilized powder at -20 °C, protected from light. Because the sequence contains two acidic residues (glutamate and aspartate), it is highly water-soluble and reconstitution into a neutral aqueous solvent is typically rapid. Researchers often prepare only the volume needed for an immediate run and keep the remaining lyophilized powder sealed; reconstituted material is aliquoted to limit freeze–thaw cycling. The research documentation review checklist outlines what to confirm on receipt.
Research Context
Epithalon appears in the laboratory research literature as a synthetic peptide of interest. This profile intentionally does not describe, summarize, or imply any biological activity, effect, outcome, or application. Any research use is defined and bounded by the investigating laboratory's protocols, institutional SOPs, and applicable safety and regulatory requirements.
What This Profile Does and Does Not Establish
This is a documentation reference. It does not, on its own, establish any of the following:
- That the material is appropriate for a specific research workflow — suitability is a laboratory determination made against institutional SOPs.
- That every unit in a shipment is identical to a tested sample; analysis is performed on a sample, not on each container.
- Any biological effect, activity, or outcome — none is claimed or implied.
- Fitness for human or veterinary use, diagnosis, treatment, or consumption. Epithalon is supplied for laboratory research use only.
Key Takeaways
- Epithalon is a synthetic tetrapeptide, Ala-Glu-Asp-Gly (CAS 307297-39-8; ~390.3 Da), supplied as a lyophilized powder for research use only.
- Identity is confirmed by LC-MS; purity is reported by RP-HPLC — two distinct, complementary methods.
- Each lot carries a COA, an RP-HPLC purity report, and an independent third-party report tied by a lot identifier.
- Reported values describe a tested sample under stated methods — not suitability, uniformity, or any use.
